Basic Information

Terpenoid ID TKC013736
Cell line 0
Protein target 18
DiseaseNCIT 0
ORDO 0
ICD 45

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC013736 HepG2 22387.0 nM Potency C3728 Orphanet_449
TKC013736 Hepatocyte 6.0 pmol/min/10^6cells Vmax
TKC013736 INS1(832/13) INS1 832/13; INS-1 (832/13); INS 832/13; 832/13; 832/13 INS-1 1250.0 nM IC50 C121566

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC013736 P11473 Vitamin D3 receptor VDR 11220 nM Potency
TKC013736 P08684 Cytochrome P450 3A4 CYP3A4 8700 nM Km
TKC013736 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 83 % Inhibition
TKC013736 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 88 % Inhibition
TKC013736 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 23109 nM Potency
TKC013736 P08183 ATP-dependent translocase ABCB1 ABCB1 35 % Inhibition
TKC013736 P0DTD1 Replicase polyprotein 1ab rep 4 % Inhibition
TKC013736 P28482 Mitogen-activated protein kinase 1 MAPK1 6310 nM Potency
TKC013736 P08659 Luciferin 4-monooxygenase 8492 nM Potency
TKC013736 P63096 Guanine nucleotide-binding protein G GNAI1 31623 nM Potency
TKC013736 O97447 Putative fructose-1,6-bisphosphate aldolase fba 17741 nM Potency
TKC013736 Q92830 Histone acetyltransferase KAT2A KAT2A 11220 nM Potency
TKC013736 P51450 Nuclear receptor ROR-gamma Rorc 35481 nM Potency
TKC013736 P02545 Prelamin-A/C LMNA 398 nM Potency
TKC013736 P0A0J7 Quinolone resistance protein NorA norA 14 % Inhibition
TKC013736 P10632 Cytochrome P450 2C8 CYP2C8 5700 nM Km
TKC013736 Q8WZA2 Rap guanine nucleotide exchange factor 4 RAPGEF4 35481 nM Potency
TKC013736 O15245 Solute carrier family 22 member 1 SLC22A1 9200 nM IC50
TKC013736 O15438 ATP-binding cassette sub-family C member 3 ABCC3 16700 nM IC50
TKC013736 O15439 ATP-binding cassette sub-family C member 4 ABCC4 53900 nM IC50
TKC013736 O94956 Solute carrier organic anion transporter family member 2B1 SLCO2B1 42 % Inhibition
TKC013736 O95342 Bile salt export pump ABCB11 22000 nM IC50
TKC013736 P20815 Cytochrome P450 3A5 CYP3A5 0 uL/min/nmol CL free
TKC013736 Q09428 ATP-binding cassette sub-family C member 8 ABCC8 50 nM Kd
TKC013736 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 72300 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P08183 MDR1_HUMAN Lung cancer [ICD-11: 2C25]
P08183 MDR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08183 MDR1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P08183 MDR1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P08183 MDR1_HUMAN Adrenal cancer [ICD-11: 2D11]
P08183 MDR1_HUMAN Ovarian cancer [ICD-11: 2C73]
P28482 MK01_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Pancreatic cancer [ICD-11: 2C10]
P28482 MK01_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P28482 MK01_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P28482 MK01_HUMAN Transplant rejection [ICD-11: NE84]
P28482 MK01_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P28482 MK01_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q09428 ABCC8_HUMAN Acute diabete complication [ICD-11: 5A2Y]
Q09428 ABCC8_HUMAN Ischaemic/haemorrhagic stroke [ICD-11: 8B20]
Q09428 ABCC8_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q09428 ABCC8_HUMAN Diabetes mellitus [ICD-11: 5A10]
Q09428 ABCC8_HUMAN Supraventricular tachyarrhythmia [ICD-11: BC81]