Basic Information

Terpenoid ID TKC011412
Chirality TKC151758
Cell line 0
Protein target 20
DiseaseNCIT 0
ORDO 0
ICD 55

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC011412 MRC5 MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5 21800.0 nM IC50
TKC011412 AGS 89800.0 nM IC50 C4004
TKC011412 HepG2 41300.0 nM IC50 C3728 Orphanet_449
TKC011412 MDA-N MDAN 32434.0 nM GI50 C3802
TKC011412 SN12C SN-12C 23988.0 nM GI50 C9385 Orphanet_217071
TKC011412 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 19953.0 nM GI50 C3512
TKC011412 ACHN 13428.0 nM GI50 C6975 Orphanet_319298
TKC011412 UO-31 UO.31; UO31; U031 14355.0 nM GI50 C9385 Orphanet_217071
TKC011412 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 6223.0 nM GI50 C2926
TKC011412 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 25061.0 nM GI50 C4863
TKC011412 SF-539 SF-539; SF-539 BT; SF.539; SF 539 18707.0 nM GI50 C3796 Orphanet_251576
TKC011412 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 16181.0 nM GI50 C3510
TKC011412 K562 K562; K.562; K 562; KO; GM05372; GM05372E 28445.0 nM GI50 C9110 Orphanet_521
TKC011412 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 22699.0 nM GI50 C105555
TKC011412 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 11803.0 nM GI50 C9142 Orphanet_99861
TKC011412 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 27227.0 nM GI50 C3512
TKC011412 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 13804.0 nM GI50 C60781 Orphanet_94
TKC011412 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 15631.0 nM GI50 C105555
TKC011412 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 20797.0 nM GI50 C105555
TKC011412 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 15346.0 nM GI50 C105555
TKC011412 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 31769.0 nM GI50 C5214
TKC011412 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 10000.0 nM GI50 C60781 Orphanet_94
TKC011412 TK-10 TK.10; TK 10; TK10 13428.0 nM GI50 C4033 Orphanet_319276
TKC011412 SR SR-786; SR786 5333.0 nM GI50 C37193 Orphanet_300895
TKC011412 SW-620 SW-620; SW 620; SW.620 31842.0 nM GI50 C4349
TKC011412 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 12972.0 nM GI50 C3512
TKC011412 KM12 KM-12; KM.12 14028.0 nM GI50 C4910
TKC011412 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 33420.0 nM GI50 C2923
TKC011412 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 7482.0 nM GI50 C3242 Orphanet_29073
TKC011412 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 39537.0 nM GI50 C105555
TKC011412 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 19588.0 nM GI50 C3802
TKC011412 BT-549 BT 549; BT.549; BT549 10544.0 nM GI50 C4194
TKC011412 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 18923.0 nM GI50 C3224
TKC011412 A549 18197.0 nM GI50 C3512
TKC011412 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 17824.0 nM GI50 C3058 Orphanet_360
TKC011412 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 13243.0 nM GI50 C4349
TKC011412 HCT-15 HCT-15; HCT.15; HCT15 27290.0 nM GI50 C4349
TKC011412 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 8670.0 nM IC50 C4910
TKC011412 SF-268 SF-268; SF.268; SF 268 18836.0 nM GI50 C60781 Orphanet_94
TKC011412 PC-3 PC3; PC.3 15311.0 nM GI50 C4863
TKC011412 MCF7 18880.0 nM GI50 C4194
TKC011412 EKVX 15885.0 nM GI50 C3512
TKC011412 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 37325.0 nM GI50 C7978
TKC011412 T47D 18408.0 nM GI50 C4194
TKC011412 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 19861.0 nM GI50 C4450
TKC011412 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 13868.0 nM GI50 C3224
TKC011412 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 27797.0 nM GI50 C3224
TKC011412 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 16255.0 nM GI50 C3802
TKC011412 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 19409.0 nM GI50 C7979 Orphanet_454723
TKC011412 SF-295 SF-295; SF.295; SF 295 22387.0 nM GI50 C3058 Orphanet_360
TKC011412 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 24099.0 nM GI50 C4194
TKC011412 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 14555.0 nM GI50 C3224
TKC011412 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 30974.0 nM GI50 C9385 Orphanet_217071
TKC011412 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 3184.0 nM GI50 C7953 Orphanet_99861
TKC011412 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 10351.0 nM GI50 C45662 Orphanet_50251
TKC011412 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 13152.0 nM GI50 C3510
TKC011412 HT-29 HT 29; HT29 20190.0 nM IC50 C4349
TKC011412 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 19634.0 nM GI50 C9385 Orphanet_217071
TKC011412 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 24155.0 nM GI50 C4349
TKC011412 Hepatocyte 95700.0 nM EC50
TKC011412 PANC-1 Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P 150000.0 nM EC50 C9120
TKC011412 MIA PaCa-2 MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa 5500.0 nM EC50 C9120
TKC011412 SW480 SW-480; SW 480; SW480E 10490.0 nM IC50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC011412 P00352 Retinal dehydrogenase 1 ALDH1A1 14125 nM Potency
TKC011412 P10636 Microtubule-associated protein tau MAPT 8913 nM Potency
TKC011412 P11473 Vitamin D3 receptor VDR 19953 nM Potency
TKC011412 P08684 Cytochrome P450 3A4 CYP3A4 4300 nM Ki
TKC011412 O14684 Prostaglandin E synthase PTGES 5000 nM IC50
TKC011412 P14324 Farnesyl pyrophosphate synthase FDPS 20000 nM IC50
TKC011412 P16233 Pancreatic triacylglycerol lipase PNLIP 36000 nM IC50
TKC011412 Q72874 Protease pol 240 nM IC50
TKC011412 P05177 Cytochrome P450 1A2 CYP1A2 <11 % Inhibition
TKC011412 P05181 Cytochrome P450 2E1 CYP2E1 <11 % Inhibition
TKC011412 P10635 Cytochrome P450 2D6 CYP2D6 <11 % Inhibition
TKC011412 P11712 Cytochrome P450 2C9 CYP2C9 9200 nM Ki
TKC011412 P33261 Cytochrome P450 2C19 CYP2C19 <11 % Inhibition
TKC011412 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 3548 nM Potency
TKC011412 O00255 Menin MEN1 22387 nM Potency
TKC011412 O15296 Polyunsaturated fatty acid lipoxygenase ALOX15B ALOX15B 355 nM Potency
TKC011412 O97447 Putative fructose-1,6-bisphosphate aldolase fba 9976 nM Potency
TKC011412 P02791 Ferritin light chain FTL 25119 nM Potency
TKC011412 P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD 15849 nM Potency
TKC011412 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 1413 nM Potency
TKC011412 P18054 Polyunsaturated fatty acid lipoxygenase ALOX12 ALOX12 1995 nM Potency
TKC011412 P35222 Catenin beta-1 CTNNB1 5213 nM IC50
TKC011412 P51450 Nuclear receptor ROR-gamma Rorc 15849 nM Potency
TKC011412 P0A0J7 Quinolone resistance protein NorA norA 2 ug.mL-1 MIC
TKC011412 P10632 Cytochrome P450 2C8 CYP2C8 <11 % Inhibition
TKC011412 P20813 Cytochrome P450 2B6 CYP2B6 <11 % Inhibition
TKC011412 P78417 Glutathione S-transferase omega-1 GSTO1 62000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
O14684 PTGES_HUMAN Alzheimer disease [ICD-11: 8A20]
O14684 PTGES_HUMAN Circulatory system disease [ICD-11: BE2Z]
O14684 PTGES_HUMAN Joint pain [ICD-11: ME82]
O14684 PTGES_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P14324 FPPS_HUMAN Bone paget disease [ICD-11: FB85]
P14324 FPPS_HUMAN Focal/segmental autonomic disorder [ICD-11: 8D8A]
P14324 FPPS_HUMAN Low bone mass disorder [ICD-11: FB83]
P14324 FPPS_HUMAN Mineral excesses [ICD-11: 5B91]
P14324 FPPS_HUMAN Musculoskeletal system/connective tissue disease [ICD-11: FC0Z]
P14324 FPPS_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P14324 FPPS_HUMAN Colorectal cancer [ICD-11: 2B91]
P14324 FPPS_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P14324 FPPS_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P14324 FPPS_HUMAN Myeloproliferative neoplasm [ICD-11: 2A20]
P14324 FPPS_HUMAN Pancreatic cancer [ICD-11: 2C10]
P14324 FPPS_HUMAN Sexually transmitted infection [ICD-11: 1A9Y-1A9Z]
P14324 FPPS_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P16233 LIPP_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P16233 LIPP_HUMAN Obesity [ICD-11: 5B80-5B81]
P16233 LIPP_HUMAN Pancreatic malfunction [ICD-11: DC30-DC3Z]
P16233 LIPP_HUMAN Cystic fibrosis [ICD-11: CA25]
P16233 LIPP_HUMAN Pancreas disease [ICD-11: DC35-DC3Z]
P10635 CP2D6_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
P10635 CP2D6_HUMAN Malaria [ICD-11: 1F40-1F45]
P10635 CP2D6_HUMAN Migraine [ICD-11: 8A80]
P11712 CP2C9_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P35222 CTNB1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P35222 CTNB1_HUMAN Colon cancer [ICD-11: 2B90]
P35222 CTNB1_HUMAN Systemic sclerosis [ICD-11: 4A42]
P78417 GSTO1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]