Basic Information

Terpenoid ID TKC011384
Chirality TKC151910
Cell line 0
Protein target 15
DiseaseNCIT 0
ORDO 0
ICD 23

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC011384 Raji RAJI; P1-Raji; GM04671 60.0 % Activity C27694 Orphanet_543

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC011384 P10636 Microtubule-associated protein tau MAPT 39811 nM Potency
TKC011384 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 2593 nM Potency
TKC011384 O95398 Rap guanine nucleotide exchange factor 3 RAPGEF3 89125 nM Potency
TKC011384 P53350 Serine/threonine-protein kinase PLK1 PLK1 18888 nM Potency
TKC011384 Q14191 Werner syndrome ATP-dependent helicase WRN 50119 nM Potency
TKC011384 O75164 Lysine-specific demethylase 4A KDM4A 56234 nM Potency
TKC011384 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 39811 nM Potency
TKC011384 Q962Y6 Thioredoxin glutathione reductase TGR 31623 nM Potency
TKC011384 Q9UBT6 DNA polymerase kappa POLK 15849 nM Potency
TKC011384 Q9UNA4 DNA polymerase iota POLI 10000 nM Potency
TKC011384 P39748 Flap endonuclease 1 FEN1 50119 nM Potency
TKC011384 P63096 Guanine nucleotide-binding protein G GNAI1 10000 nM Potency
TKC011384 P06746 DNA polymerase beta POLB 17783 nM Potency
TKC011384 Q9Y253 DNA polymerase eta POLH 7080 nM Potency
TKC011384 O94925 Glutaminase kidney isoform, mitochondrial GLS 11220 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
O95398 RPGF3_HUMAN Epidermal dysplasias [ICD-11: EK90]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q14191 WRN_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P06746 DPOLB_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]