Basic Information

Terpenoid ID TKC009499
Cell line 0
Protein target 7
DiseaseNCIT 0
ORDO 0
ICD 6

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC009499 RAW264.7 RAW264 76.0 ug.mL-1 IC50 C21604
TKC009499 C6 C-6; C 6; RGC-6; RGC6; RGc6 94.0 % Activity C64069

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC009499 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 11220 nM Potency
TKC009499 Q9UNA4 DNA polymerase iota POLI 28184 nM Potency
TKC009499 P63096 Guanine nucleotide-binding protein G GNAI1 891 nM Potency
TKC009499 P06746 DNA polymerase beta POLB 39811 nM Potency
TKC009499 Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B BAZ2B 70795 nM Potency
TKC009499 Q9Y253 DNA polymerase eta POLH 28184 nM Potency
TKC009499 P52333 Tyrosine-protein kinase JAK3 JAK3 >100 nM IC50
TKC009499 Q15046 Lysine--tRNA ligase KARS1 49 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P06746 DPOLB_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P52333 JAK3_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P52333 JAK3_HUMAN Psoriasis [ICD-11: EA90]
P52333 JAK3_HUMAN Alopecia [ICD-11: ED70]
P52333 JAK3_HUMAN Asthma [ICD-11: CA23]
P52333 JAK3_HUMAN Crohn disease [ICD-11: DD70]
P52333 JAK3_HUMAN Acquired hypomelanotic disorder [ICD-11: ED63]
P52333 JAK3_HUMAN Atopic eczema [ICD-11: EA80]
P52333 JAK3_HUMAN B-cell lymphoma [ICD-11: 2A86]
P52333 JAK3_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P52333 JAK3_HUMAN Pruritus [ICD-11: EC90]
P52333 JAK3_HUMAN Multiple myeloma [ICD-11: 2A83]
P52333 JAK3_HUMAN Transplant rejection [ICD-11: NE84]
P52333 JAK3_HUMAN Diabetes mellitus [ICD-11: 5A10]
P52333 JAK3_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
P52333 JAK3_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]