Basic Information

Terpenoid ID TKC005842
Chirality TKC070444
Cell line 0
Protein target 7
DiseaseNCIT 0
ORDO 0
ICD 14

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC005842 KB KB (HeLa derivative); HeLa-KB; Strain KB 1.0 ug ml-1 ED50 C27677
TKC005842 A498 A498 27.0 % Inhibition C9385 Orphanet_217071
TKC005842 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 6.0 % Inhibition C45662 Orphanet_50251
TKC005842 A549 21000.0 nM IC50 C3512
TKC005842 PC-3 PC3; PC.3 2.0 % Inhibition C4863
TKC005842 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 3100.0 nM IC50 C4450
TKC005842 MCF7 17000.0 nM IC50 C4194

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC005842 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 9200 nM Potency
TKC005842 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 20596 nM Potency
TKC005842 P43220 Glucagon-like peptide 1 receptor GLP1R 8913 nM Potency
TKC005842 O75496 Geminin GMNN 23109 nM Potency
TKC005842 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 8913 nM Potency
TKC005842 P0DTD1 Replicase polyprotein 1ab rep -8 % Inhibition
TKC005842 P00811 Beta-lactamase ampC 1413 nM Potency
TKC005842 Q9Y253 DNA polymerase eta POLH 100000 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]