Basic Information

Terpenoid ID TKC002371
Cell line 0
Protein target 14
DiseaseNCIT 0
ORDO 0
ICD 46

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC002371 HCT-15 HCT-15; HCT.15; HCT15 552.0 nM GI50 C4349
TKC002371 HepG2 35481.0 nM Potency C3728 Orphanet_449
TKC002371 HEK293 12589.0 nM Potency
TKC002371 SN12C SN-12C 2529.0 nM GI50 C9385 Orphanet_217071
TKC002371 MDA-N MDAN 1400.0 nM GI50 C3802
TKC002371 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 2642.0 nM GI50 C3512
TKC002371 ACHN 1122.0 nM GI50 C6975 Orphanet_319298
TKC002371 UO-31 UO.31; UO31; U031 2061.0 nM GI50 C9385 Orphanet_217071
TKC002371 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 4217.0 nM GI50 C2926
TKC002371 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 288.0 nM GI50 C9154 Orphanet_519
TKC002371 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 3034.0 nM GI50 C4863
TKC002371 SF-539 SF-539; SF-539 BT; SF.539; SF 539 2099.0 nM GI50 C3796 Orphanet_251576
TKC002371 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 1816.0 nM GI50 C3510
TKC002371 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 2366.0 nM GI50 C3224
TKC002371 K562 K562; K.562; K 562; KO; GM05372; GM05372E 352.0 nM GI50 C9110 Orphanet_521
TKC002371 A498 A498 3184.0 nM GI50 C9385 Orphanet_217071
TKC002371 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 3733.0 nM GI50 C105555
TKC002371 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 661.0 nM GI50 C9142 Orphanet_99861
TKC002371 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 8453.0 nM GI50 C3512
TKC002371 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 2931.0 nM GI50 C60781 Orphanet_94
TKC002371 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 4112.0 nM GI50 C105555
TKC002371 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 3811.0 nM GI50 C105555
TKC002371 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 5321.0 nM GI50 C105555
TKC002371 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 3581.0 nM GI50 C60781 Orphanet_94
TKC002371 SR SR-786; SR786 347.0 nM GI50 C37193 Orphanet_300895
TKC002371 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 4645.0 nM GI50 C5214
TKC002371 TK-10 TK.10; TK 10; TK10 5861.0 nM GI50 C4033 Orphanet_319276
TKC002371 SW-620 SW-620; SW 620; SW.620 2421.0 nM GI50 C4349
TKC002371 KM12 KM-12; KM.12 3311.0 nM GI50 C4910
TKC002371 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 522.0 nM GI50 C3512
TKC002371 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 2642.0 nM GI50 C3802
TKC002371 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 12190.0 nM GI50 C2923
TKC002371 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 2529.0 nM GI50 C3242 Orphanet_29073
TKC002371 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 2173.0 nM GI50 C105555
TKC002371 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 1140.0 nM GI50 C3802
TKC002371 BT-549 BT 549; BT.549; BT549 3076.0 nM GI50 C4194
TKC002371 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 5000.0 nM GI50 C3224
TKC002371 A549 4375.0 nM GI50 C3512
TKC002371 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 8318.0 nM GI50 C3058 Orphanet_360
TKC002371 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 1945.0 nM GI50 C4349
TKC002371 SF-268 SF-268; SF.268; SF 268 3404.0 nM GI50 C60781 Orphanet_94
TKC002371 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 1600.0 nM GI50 C4910
TKC002371 MCF7 798.0 nM GI50 C4194
TKC002371 EKVX 3908.0 nM GI50 C3512
TKC002371 PC-3 PC3; PC.3 7194.0 nM GI50 C4863
TKC002371 T47D 3741.0 nM GI50 C4194
TKC002371 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 8954.0 nM GI50 C7978
TKC002371 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 2270.0 nM GI50 C3224
TKC002371 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 1626.0 nM GI50 C4450
TKC002371 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1758.0 nM GI50 C3224
TKC002371 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 3243.0 nM GI50 C3802
TKC002371 SF-295 SF-295; SF.295; SF 295 9311.0 nM GI50 C3058 Orphanet_360
TKC002371 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 3034.0 nM GI50 C7979 Orphanet_454723
TKC002371 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 3581.0 nM GI50 C4194
TKC002371 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 3733.0 nM GI50 C3224
TKC002371 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 3013.0 nM GI50 C9385 Orphanet_217071
TKC002371 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 392.0 nM GI50 C7953 Orphanet_99861
TKC002371 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 7762.0 nM GI50 C45662 Orphanet_50251
TKC002371 HT-29 HT 29; HT29 1349.0 nM GI50 C4349
TKC002371 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 3656.0 nM GI50 C3510
TKC002371 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 2234.0 nM GI50 C9385 Orphanet_217071
TKC002371 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 771.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC002371 P11473 Vitamin D3 receptor VDR 89125 nM Potency
TKC002371 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 2060 nM Potency
TKC002371 P43220 Glucagon-like peptide 1 receptor GLP1R 891 nM Potency
TKC002371 P84022 Mothers against decapentaplegic homolog 3 SMAD3 2818 nM Potency
TKC002371 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 15849 nM Potency
TKC002371 Q06710 Paired box protein Pax-8 PAX8 <1430 nM AC50
TKC002371 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 5623 nM Potency
TKC002371 Q99700 Ataxin-2 ATXN2 28184 nM Potency
TKC002371 O75496 Geminin GMNN 2060 nM Potency
TKC002371 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 50119 nM Potency
TKC002371 P01215 Glycoprotein hormones alpha chain CGA 316 nM Potency
TKC002371 P03230 Latent membrane protein 1 LMP1 5137 nM AC50
TKC002371 P37840 Alpha-synuclein SNCA 35481 nM Potency
TKC002371 P38398 Breast cancer type 1 susceptibility protein BRCA1 5012 nM Potency
TKC002371 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 11220 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]