Basic Information

Terpenoid ID TKC001930
Chirality TKC151881
Cell line 0
Protein target 8
DiseaseNCIT 0
ORDO 0
ICD 21

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC001930 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 81.0 uM IG50 C60781 Orphanet_94
TKC001930 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 2.0 uM IG50 C4863
TKC001930 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 25620.0 nM GI50 C9154 Orphanet_519
TKC001930 A549 28.0 uM ED50 C3512
TKC001930 5637 45.0 % Inhibition C4912
TKC001930 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 149.0 ug.mL-1 IC50 C27677
TKC001930 ACHN 328.0 ug.mL-1 IC50 C6975 Orphanet_319298
TKC001930 B16 B-16; B16 melanoma; B16 subline B78; B78 25.0 ug.mL-1 IC50 C21790
TKC001930 P388 P-388 35.0 uM ED50 C21602
TKC001930 KB KB (HeLa derivative); HeLa-KB; Strain KB 5.0 uM ED50 C27677
TKC001930 HT-29 HT 29; HT29 29.0 uM ED50 C4349
TKC001930 MCF7 19.0 uM ED50 C4194
TKC001930 HEK293 8.0 uM ED50
TKC001930 NIH3T3 NIH/3T3; NIH-3T3; NIH3T3; 3T3; 3T3NIH; 3T3-Swiss; Swiss-3T3; Swiss/3T3; Swiss 3T3; Swiss3T3 64270.0 nM IC50
TKC001930 PC-12 PC 12; PC12 19.0 % Activity C5650

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC001930 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 29093 nM Potency
TKC001930 O43451 Maltase-glucoamylase, intestinal MGAM 17 % Inhibition
TKC001930 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 50119 nM Potency
TKC001930 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 20596 nM Potency
TKC001930 O75164 Lysine-specific demethylase 4A KDM4A 89125 nM Potency
TKC001930 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 31623 nM Potency
TKC001930 Q962Y6 Thioredoxin glutathione reductase TGR 39811 nM Potency
TKC001930 Q9UBT6 DNA polymerase kappa POLK 89125 nM Potency
TKC001930 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O43451 MGA_HUMAN Acute diabete complication [ICD-11: 5A2Y]
O43451 MGA_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
O43451 MGA_HUMAN Inborn carbohydrate metabolism error [ICD-11: 5C51]
O43451 MGA_HUMAN Muscle disorder [ICD-11: FB32-FB3Z]
O43451 MGA_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
O43451 MGA_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
O43451 MGA_HUMAN Dengue fever [ICD-11: 1D2Z]
O43451 MGA_HUMAN Blood chemistry clinical sympton [ICD-11: MA18]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]